Behavioral and Side Effects of Caffeine :: Coffee Caffeine Science Chemistry Research Papers

Behavioral and Side Effects of CaffeineCaffeine is the most consumed mind-altering drug in the world (Solinas et al, 2002). Caffeine has been known to have many an(prenominal) side effects on hour external behavior and our infixed physiological behavior. We use caffeine in our lives to sometimes stay stir up to study or just get through the day. Caffeine decreases the tide rip menstruum to the headspring by constricting the blood vessels but seat also increase blood flow after continuous use that may cause headaches (Kalat, 2004). Caffeine has a tendency to block adenosine (A1-, A2A-, A2B-, A3), which increases throughout the day to allow us to tranquillity and then decreases as we sleep which allows us to wake. Thus, if caffeine blocks adenosine we are unable to sleep when feeling the iron or wanting to sleep, which may cause us to decrease our caffeine intake. Caffeine acts to antagonize adenosine receptors, which then affects cell populations because it counteract s many adenosine effects. The caffeine mainly has an effect on the A2a adenosine receptors which then elevates the energy metabolism in the brain and also causes a decrease in cerebral blood flow (Cameron,et.al, 1990 Ghelardini, et.al, 1997 Nehliget.al,1992 Neuhauser-Berthold et.al, 1997). Along with caffeine affecting the adenosine it also has an effect on gamma aminobutyric acid receptors and the release of dopamine (Nehlig et.al, 1992).Caffeine not only blockades adenosine it also releases intracellular calcium, inhibits phosphodiesterases and blockade or regulatory sites of GABAa-receptors (Gupta and Gupta, 1999). Withdrawal symptoms of caffeine are headache, drowsiness, jade and lethargy (Gupta and Gupta, 1999). Dopamine and glutamate neurotransmission is modulated by adenosine in the striatum. Adenosine A1 in the nerve terminals inhibits dopamine and glutamate from being released. Caffeine has an effect in this system by antagonizing of adenosine, which raise then stimu late neurotransmitters to release dopamine and stimulate dopamine receptors (Solinas et al, 2002). A study done on rats depicted that caffeine increased extracelluar concentrations of dopamine and glutamate in the shell of the nucleus accumbens (Solinas et al, 2002). These results of dopamine and glutamate in the shell of the nucleus accumbens mightiness be related to the psycho stimulant effects of caffeine (Solinas et al, 2002). Studies show that Dopamine2 receptors are needed for caffeine activation in the brain (Zahniseret al, 2000). Adenosine receptors, dopamine receptors and GABA have been shown in studies to be involved in